学术报告首页>学术报告

中科院计算生物学重点实验室学术报告:Convergent mechanisms of longevity

副标题:

时间:2017-11-03  来源:文本大小:【 |  | 】  【打印

Speaker: Adam Antebi, PhD
          Managing Director,Max Planck Institute for Biology of Ageing, Cologne, Germany 
          Web: https://www.age.mpg.de/science/research-labs/antebi/

Time : 4:00-6:00 pm , Nov. 10(Friday)
Venue: Room 300, SIBS Main Building, Yueyang Road 320
Host:Prof. Jingdong Han 
       CAS-MPG Partner Institute for Computational Biology

Title:Convergent mechanisms of longevity

Abstract:

       Research in model organisms over the last several decades has revealed that animal lifespan is plastic and regulated by conserved metabolic signaling pathways, which work through specific transcription factors to extend life. Whether these pathways affect common downstream mechanisms remains largely elusive. Our studies in C. elegans reveal that an extensive helix-loop-helix transcription factor network regulates life span across the major longevity pathways, and is interlinked via mTOR signaling. More recently, we have discovered that a major focal point of convergent regulation is the nucleolus. NCL-1/TRIM2/Brat tumor suppressor extends lifespan and limits nucleolar size in the major C. elegans longevity pathways. Animals representing distinct longevity pathways exhibit small nucleoli, and decreased expression of rRNA, ribosomal proteins, and the nucleolar protein fibrillarin, dependent on NCL-1. Fibrillarin is not only a marker but itself a causal factor whose knockdown reduces nucleolar size and extends lifespan. Among wild type C. elegans, individual nucleolar size varies, but is highly correlated for life expectancy; those with smaller nucleoli live longer, while those with larger nucleoli live shorter. Long-lived dietary restricted fruit flies and insulin-like-peptide mutants also exhibit reduced nucleoli and fibrillarin expression. Similarly, tissues derived from long-lived dietary restricted and reduced insulin/IGF signaling IRS1 knockout mice display reduced nucleoli. We suggest that small nucleoli are a cellular hallmark of longevity conserved across taxa.

       All are welcome!

相关附件
相关文档
2014 中国科学院上海生命科学研究院 版权所有
地址:上海岳阳路320号 邮编:200031 电话:86-21-54920000 传真:86-21-54920078
电子信箱:webmaster@sibs.ac.cn